Objective: To evaluate the efficacy of muscular amino acids and nucleosides with small-dose asipirin in effect of Treating early-onset severe pre-eclampsia Pregnant women .Methods: This study is a randomized, single-blind, prospective study, in December 2007 to January 2009, and to select 83 cases of early-onset severe pre-eclampsia Pregnant women from the second Clinical Hospital of Jilin University obstetric hospital in line with the standard of study . All the objects were divided into 4 groups. 21 cases of which the magnesium sulfate group: 25% Glucose 60ml  5% magnesium sulfate 500ml, Qd, iv, as a rate of 1-2g / h. Small-dose aspirin   magnesium sulfate group of 22 cases: 25% Glucose 60ml  5% magnesium sulfate 500ml, Qd, iv,as a rate of 1-2g / h; small-dose aspirin, 75mg / d , po. muscular amino acids and nucleosides   magnesium sulfate group 19 cases: 25% Glucose 60ml  5% magnesium sulfate 500ml, Qd, iv, as a rate of 1-2g / h; muscular amino acids and nucleosides 20ml  5% glucose 250ml, Qd, iv. Small-dose aspirin   muscular amino acids and nucleosides   magnesium group 21 cases: 25% Glucose 60ml  5% magnesium sulfate 500ml, Qd, iv, as a rate of 1-2g / h; small-dose aspirin Afghanistan Lin, 75mg / d, pol; muscular amino acids and nucleosides 20ml   5% glucose 250 ml, Qd, iv. Observation:①to observe symptoms such as swelling of the body changes of early-onset severe pre-eclampsia Pregnant women from admitted to the hospital to discharge, and to monitor blood pressure of the daily continuous changes;②to observe and record from admitted to the hospital before the treatment given ,three days later and seven days later before the termination of pregnancy and when early-onset severe pre-eclampsia Pregnant women discharged of the changes in urinary protein;③laboratory indicators: changes in plasma ET;④observation of when early-onset severe pre-eclampsia Pregnant women were admitted to the hospital ,during treatment of fetal distress, the birth weight and apgar score in the time of termination of pregnancy, and the extended time of gestational age ;⑤adverse reactions.Results:①The blood pressure and edema in pregnant women: to observe the dynamic changes in hospital,select an analysis of data comparison of the admission before the beginning of treatment ,1 day later ,3 days later, 7 days later when treatment was given ,the time prior to termination of pregnancy, and when they were discharged (by table 1). Changes in blood pressure in pregnant women: the group given by small-dose aspirin or muscle amino peptidase glycosides on the basis of magnesium sulfate reached the target blood pressure earlier than treatment with magnesium sulfate group, the group given by small-dose aspirin and muscular amino acids and nucleosides achieve the target blood pressure treatment significantly earlier than the magnesium sulfate group ,but also earlier the other two groups; Changes of the edema in pregnant women ,the group given by small-dose aspirin or muscular amino acids and nucleosides based on the therapy of magnesium sulfate improve in the edema of pregnant women ,the group in the use of small-dose aspirin and muscular amino acids and nucleosides based on the therapy of magnesium sulfate significantly improve in the edema of pregnant women ; overall, the changes in blood pressure were slow comparing with the changes in edema (by Table 1).②The urine protein measurements :an analysis of data comparison in the admission and different time periods during the treatment of pregnant women, the urine protein measurements was slightly lower in the four group ,the disparation of the changes of the four groups have no significant difference (p> 0.05),that is, the changes of the urine protein in the admission and different time periods during the treatment of pregnant women decrease less obviously; when every pregnant women discharge, the difference of measurements of urinary protein in the four group groups possess statistically significantce(p <0.05), that is, the changes of the urine protein in the group of small-dose aspirin or muscular amino acids and nucleosides based on the therapy of magnesium sulfate significantly decreased more significantly, the group given by small-dose aspirin and muscular amino acids and nucleosides based on the therapy of magnesium sulfate decreased,and also more significantly than the other two groups decreased significantly (by Table 2).③Plasma ET: pregnant women in admission, different stages of treatment time and discharge , the content of plasma ET decreased, the decreased differences of plasma ET at different time points possess statistically significance (p <0.05), that is, the group of small-dose aspirin or muscular amino acids and nucleosides on basis of the therapy of decreased significantly ,comparing the magnesium sulfate group in the plasma ET content, the group of small-dose aspirin and muscular amino acids and nucleosides decreased significantly than the magnesium sulfate group in the plasma ET content, more than the other two groups decreased. (by Table 3)④fetal distress in uterus: the percentage of fetal distress in uterus in the group of small-dose aspirin or (and) muscular amino acids and nucleosides on basis of the therapy of magnesium sulfate was lower than the magnesium sulfate group ,the differences of the three groups in the percentage comparing with the magnesium sulfate group them possess statistically significance(p <0.05), that is, the percentage of fetal distress in uterus in the group of small-dose aspirin or muscular amino acids and nucleosides degraded more significantly than the magnesium sulfate group in of the reduced proportion of the cases of fetal distress in uterus, the intrauterine state of fetal improve better, the percentage of fetal distress in uterus in the group of small-dose aspirin and muscular amino acids and nucleosides on the basis of magnesium sulfate degraded more significantly than the magnesium sulfate group in of the reduced proportion of the cases of fetal distress in uterus, the intrauterine state of fetal improved better, and degraded more significantly than the other two groups , the intrauterine state of fetal improved significantly better. Birth weight: the birth weight distribution significance in the group of small-dose aspirin or (and) muscular amino acids and nucleosides on the basis of the magnesium sulfate possess the statistical of differences(p <0.05), that is, the group of small-dose aspirin or muscular amino acids and nucleosides on the basis of the magnesium sulfate have greater proportion of high-2.5Kg of newborn infant ,and the lower proportion of low-2.5Kg of newborn infant conrresped the gestational age, the group of small-dose aspirin and muscular amino acids and nucleosides on the basis of magnesium sulfate have greater proportion of high-2.5Kg of newborn infant and the lower proportion of low-2.5Kg of newborn infant conrresped the gestational age than the magnesium sulfate group, and also than the other two groups. Apgar score: the Apgar score distribution differences between the groups of small-dose aspirin or (and) muscular amino acids and nucleosides on the basis of magnesium sulfate and the magnesium sulfate group possess statistically significance(p <0.05), that is, the group of small-dose aspirin or muscular amino acids and nucleosides on the basis of magnesium sulfate have the greater proportion of Apgar score at birth more than 7 points,and the lower proportion of Apgar score at birth less than 7 points than magnesium sulfate group , that proved that the situation of newborns proved better, the survival ratio was higher, the group of small-dose aspirin therapy muscular amino acids and nucleosides on the basis of magnesium sulfate have the greater proportion of Apgar score at birth more than 7 points higher ,and the lower proportion of the low-score cases of Apgar score at birth than magnesium sulfate group, that proved that the situation of newborns proved better, the survival ratio was higher, and also better than the other two groups. The extended gestational age: the differences of the extended gestational age comparing the groups of small-dose aspirin or (and) muscular amino acids and nucleosides on the basis of magnesium sulfate with the magnesium sulfate group in pregnant women of early-onset severe pre-eclampsia possess statistical significance(p <0.05), that is, the group of small-dose aspirin or muscular amino acids and nucleosides on the basis of the magnesium sulfate were more than the magnesium sulfate group in the extension of gestational time, the group of small-dose aspirin and muscular amino acids and nucleosides based on the treatment of magnesium sulfate extended more than the magnesium sulfate group ,and also than the other two groups ( by Table 4).⑤Adverse reaction :During the treatment of muscular amino acids and nucleosides , only one case haved been found adverse reaction, such as facial flushing, distention of head , when the first medication, the incidence was1.2%, the speed of drop was adjusted to them, the symptoms were eased, everyone can be tolerated, and can go on with the drug; the drop-speed of magnesium sulfate was strictly controlled, all patients have no adverse events occurred: the use of small-dose aspirin for all patients were not found in cases of adverse reactions, such as bleeding.Conclusion: Given by muscular amino acids and nucleosides or (and) small-dose aspirin based on the treatment of magnesium sulfate combined with magnesium sulfate treatment, pregnant women can delay the progression of the disease, alleviate symptoms, control blood pressure stability; significantly decreased plasma ET; maternal and fetal prognosis were better. And the treatment efficacy of the group of small-dose aspirin and muscular amino acids and nucleosides based on the treatment of magnesium sulfate were better than the other groups. During the treatment of early-onset severe pre-eclampsia Pregnant women by small-dose aspirin and muscular amino acids and nucleosides, there were not serious side effects found in the course of the therapy of small-dose aspirin and muscular amino acids and nucleosides; muscular amino acids and nucleosides and small-dose aspirin were safe and effective to early-onset severe pre-eclampsia Pregnant women.