[Objective]This study aimed to observe the mechanism of hepatic Ischemie-Reperfusion and the effects of propofol in rat in vivo.[Methods] Firstly, to build the model of hepatic Ischemie-Reperfusion in rat according to the method of Kobayashi, and then seventy-two Wistar rats weighing 250~350g were anesthetized with injection by intraperitoneal 3% pentobarbital 30 mg·kg~(-1)'.The animals were randomly divided into the control group(group A),ischemia and reperfusion group(group B),I/R propofol 4 mg·100g~(-1)·h~(-1) (group C), I/R  6mg·100g~(-1)·h~(-1) group(group D).Each group divided into four subgroups(n=6). Blood samples and liver tissue were obtained at 30min-ischemain and 30min-reperfusion (T_1), at 60min-ischemain and 60min(T_2), at 60min-ischemain and 120min-reperfusion(T_3). The serum levels of TNF-α and IL-10 were measured with ELISA.The activity of NF-kB were detected with EMSA.The ultramicrostructure and cell apoptosis and were observed by electron microscope.[Results] 1. The serum levels of TNF-a at T_1 and T_2 and T_3 in group B were significantly increased as compared with the group A(P0.05).