PurposesThrough the exercise intervention in people with NAFLD, analysis the levels of the lipid-related indexes and TNF-α,SREBP-1c in serum.Exploring the effect of aerobic exercise on TNF-α, SREBP-1c in NAFLD patients.Methods42 people with NAFLD,were randomly divided into: Exercise with diet control group (NDE), exercise group (NE), diet control group (ND) and the control group (NC); Through the 16-week aerobic exercise intervention and diet control, compare the liver B-mode ultrasound image changes, serum TG, LDL, HDL, ALT and TNF-α, SREBP-1c, FINS level with them-self ago.Conclusion1.Change of serum lipid levels: comparison with the experiment before, the serum levels of TG as well as LDL/HDL decreased significantly (P <0.05) in NDE, NE group. Inter-group comparison, serum TG levels as well as LDL/HDL decreased significantly (P <0.05) in NDE group than NC.2.Change of NAFLD-related indicators: serum TNF-α, SREBP-1c,FINS as well as HOMA-IR decreased significantly (P <0.05, P <0.01) in group NDE, NE after the experiment. Inter-group comparison, the serum levels of SREBP-1c, FINS as well as HOMA-IR in group NDE, NE and the serum levels of TNF-αare significantly decreased in group NDE than NC (P <0.05).3.Changes of Liver B-mode ultrasound image:After the experiment ,the Liver B-mode ultrasound image of NAFLD patients is better than before,liver lipid ectopic situation obviously improved.Conclusion1.The serum TG, TNF-α, SREBP-1c and FINS of subjects generally higher than the normal range, liver imaging data for the study of fatty liver.2.After 16-weeks of aerobic exercise intervention and diet control, BMI, WHR decreased significantly in NDE and NE group subjects , serum TG levels lower than befor, LDL/HDL decreased, indicating that aerobic exercise and diet control can effectively improve the lipid metabolic disorder.3.After 16-weeks of aerobic exercise and diet control, the liver B-mode ultrasound image of subjects showed fatty liver improved, NDE and NE group subjects serum TNF-α,SREBP-1c, FINS level as well as HOMA-IR decreased significantly, indicating that Aerobic exercise and diet control helps to reduce lipid synthesis, reduced liver lipid deposition, change the lever of NAFLD.