Objective: The goal of this clinical experiment is to probe the mechanism and therapeutic effects of BaoShen Decoction on treating Henoch-schonlein purpura nephrit(HSPN).Methods: 60 patients with HSPN of Virulent heat-evil blood stagnation were divided into 2 groups at random,each group is 30 cases,on the base the treated group was treated with BaoShen Decoction,while the control group was treated with multiglycoside tablet of tripterygium wilfordii(MTTW).The course of treatment is 1 months.We would the subjects of laborary examination before and after experiment,recorded the change of patients' clinical symptoms,at last observed the curative effects.Result: (1) The curative effects in the treated group were significantly superior to those in control group(P<0.05). (2) The treated group could improve the patients' clinical symptoms,decrease BLD PRO β2-MG of urine.Its effect was better than control group(P<0.01 or P<0.05).Conclusion: BaoShen Decoction can effective against the patients' clinical symptoms,improve the subjects of laborary examination,increase the curative effect,decrease relapse ratio.